Cerebral Edema in Patients With Large Hemispheric Infarct Undergoing Reperfusion Treatment: A HERMES Meta-Analysis

A secondary analysis of the HERMES dataset shows that patients with large infarction who undergo endovascular thrombectomy are more likely to experience cerebral edema, often with fatal consequences. This suggests that cerebral tissue responds differently depending on the state of the ischemic cascade: beneficial for salvageable tissue and detrimental for infarcted tissue. Thus highlighting the importance of efficient patient triaging in acute ischemic stroke care.

Cerebral Edema in Patients With Large Hemispheric Infarct Undergoing Reperfusion Treatment: A HERMES Meta-Analysis

Felix C. Ng, Nawaf Yassi, Gagan Sharma, Scott B. Brown, Mayank Goyal, Charles B.L.M. Majoie, Tudor G. Jovin, Michael D. Hill, Keith W. Muir, Jeffrey L. Saver, Francis Guillemin, Andrew M. Demchuk, Bijoy K. Menon, Luis San Roman, David S. Liebeskind, Philip White, Diederik W.J. Dippel, Antoni Davalos, Serge Bracard, Peter J. Mitchell, Michael J. Wald, Stephen M. Davis, Kevin N. Sheth, W. Taylor Kimberly, Bruce C.V. Campbell, and for the HERMES Collaborators

Purpose: Whether reperfusion into infarcted tissue exacerbates cerebral edema has treatment implications in patients presenting with extensive irreversible injury. We investigated the effects of endovascular thrombectomy and reperfusion on cerebral edema in patients presenting with radiological evidence of large hemispheric infarction at baseline.

Methods: In a systematic review and individual patient-level meta-analysis of 7 randomized controlled trials comparing thrombectomy versus medical therapy in anterior circulation ischemic stroke published between January 1, 2010, and May 31, 2017 (Highly Effective Reperfusion Using Multiple Endovascular Devices collaboration), we analyzed the association between thrombectomy and reperfusion with maximal midline shift (MLS) on follow-up imaging as a measure of the space-occupying effect of cerebral edema in patients with large hemispheric infarction on pretreatment imaging, defined as diffusion-magnetic resonance imaging or computed tomography (CT)-perfusion ischemic core 80 to 300 mL or noncontrast CT-Alberta Stroke Program Early CT Score ≤5. Risk of bias was assessed using the Cochrane tool.

Results: Among 1764 patients, 177 presented with large hemispheric infarction. Thrombectomy and reperfusion were associated with functional improvement (thrombectomy common odds ratio =2.30 [95% CI, 1.32–4.00]; reperfusion common odds ratio =4.73 [95% CI, 1.66–13.52]) but not MLS (thrombectomy β=−0.27 [95% CI, −1.52 to 0.98]; reperfusion β=−0.78 [95% CI, −3.07 to 1.50]) when adjusting for age, National Institutes of Health Stroke Score, glucose, and time-to-follow-up imaging. In an exploratory analysis of patients presenting with core volume >130 mL or CT-Alberta Stroke Program Early CT Score ≤3 (n=76), thrombectomy was associated with greater MLS after adjusting for age and National Institutes of Health Stroke Score (β=2.76 [95% CI, 0.33–5.20]) but not functional improvement (odds ratio, 1.71 [95% CI, 0.24–12.08]).

Conclusion: In patients presenting with large hemispheric infarction, thrombectomy and reperfusion were not associated with MLS, except in the subgroup with very large core volume (>130 mL) in whom thrombectomy was associated with increased MLS due to space-occupying ischemic edema. Mitigating cerebral edema-mediated secondary injury in patients with very large infarcts may further improve outcomes after reperfusion therapies.

Read the full paper here:

Ng FC, Yassi N, Sharma G, et al. Cerebral Edema in Patients With Large Hemispheric Infarct Undergoing Reperfusion Treatment: A HERMES Meta-Analysis [published online ahead of print, 2021 Aug 13]. Stroke. 2021;STROKEAHA120033246. doi:10.1161/STROKEAHA.120.033246

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